The miniature of the burning mansion shown at the climax of Night Monster is identical to the miniature of the burning castle shown at the climax of The Ghost of Frankenstein.

Alfred Hitchcock attended a screening of this film, as he wanted to cast Janet Shaw in his Universal production, "Shadow of a Doubt, " thoroughly enjoyed it, and was amazed at how quickly it was shot, from July 5-18, 1942, to be released October 23, on a double bill with "The Mummy's Tomb. "

The top billed stars, Bela Lugosi and Lionel Atwill, were hired for their marquee value rather than their performances. Lugosi was relegated to a supporting role as the butler. Lionel Atwill's character as one of the doctors was the first to get bumped off so he spent minimal time on this production.

The scene of a foggy forest behind the opening credits is the same as that used in opening of The Wolfman.

Part of the original Shock Theater package of 52 Universal titles released to television in 1957, followed a year later with Son of Shock, which added 20 more features.

The auto driven by the chauffeur (Leif Erickson) is a Duesenberg, manufactured in Indianapolis, IN.

Universal Pictures production number 1256.